The effectiveness of demineralized cortical bone matrix in a chronic rotator cuff tear model
Fuente
Este artículo es originalmente publicado en:
https://www.ncbi.nlm.nih.gov/pubmed/28162888
De:
Author information
- 1The John Scales Centre for Biomedical Engineering, Institute of Orthopaedics and Musculoskeletal Science, Division of Surgery and Interventional Science, University College London, The Royal National Orthopaedic Hospital Trust, Stanmore, Middlesex, UK. Electronic address: tanujan1@hotmail.com.
- 2The John Scales Centre for Biomedical Engineering, Institute of Orthopaedics and Musculoskeletal Science, Division of Surgery and Interventional Science, University College London, The Royal National Orthopaedic Hospital Trust, Stanmore, Middlesex, UK.
- 3The Shoulder and Elbow Service, The Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK.
J Shoulder Elbow Surg. 2017 Feb 2. pii: S1058-2746(17)30009-5. doi: 10.1016/j.jse.2017.01.003. [Epub ahead of print]
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© 2017 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights reserved
Abstract
BACKGROUND:
The purpose of this study was to assess the effect of demineralized bone matrix (DBM) on rotator cuff tendon-bone healing. The hypothesis was that compared with a commercially available dermal matrix scaffold, DBM would result in a higher bone mineral density and regenerate a morphologically superior enthesis in a rat model of chronic rotator cuff degeneration.
CONCLUSION:
The application of DBM to a rat model of chronic rotator cuff degeneration did not improve the composition of the healing enthesis compared with nonaugmented controls and a commercially available scaffold. However, perhaps the most important finding of this study was that the control group demonstrated a similar outcome to augmented repairs.
Resumen
ANTECEDENTES:
El propósito de este estudio fue evaluar el efecto de la matriz ósea desmineralizada (DBM) en la curación del tendón del hueso del manguito rotador. La hipótesis fue que, en comparación con un andamiaje de matriz dérmica comercialmente disponible, DBM resultaría en una mayor densidad mineral ósea y regeneraría una enthesis morfológicamente superior en un modelo de rata de degeneración crónica de manguito rotador.
CONCLUSIÓN:
La aplicación de DBM a un modelo de rata de degeneración crónica del manguito rotador no mejoró la composición de la enthesis de curación en comparación con los controles no aglutinados y un andamio comercialmente disponible. Sin embargo, quizás el hallazgo más importante de este estudio fue que el grupo control mostró un resultado similar a las reparaciones aumentadas.
Copyright © 2017 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.
KEYWORDS:
Animal model; enthesis healing; rotator cuff; scaffold; shoulder; tendon-bone; tissue engineering
- PMID: 28162888 DOI: 10.1016/j.jse.2017.01.003
- [PubMed – as supplied by publisher]